We are all aware of the point that slimming is a mega-dollar industry. With millions, otherwise huge amounts of people of all ages struggling to lose excess weight, and extremely few pharmaceutically effective medications available to assist them, the desperate public will literally clutch at straws.
Weekly sees the launch of a new “miracle” diet pill or potion plus a “surefire” diet certain to help believers shed kilos like magic.
Recently garcinia cambogia extract dr oz had become the flavour of year. Should you search the internet for facts about this exotic fruit extract you will end up assured that it is finally the miracle just about everyone has been waiting around for, which can produce dramatic fat loss. Endorsements by various TV personalities and also other luminaries have included in the allure of Garcinia cambogia slimming products.
In accordance with a newly released local study in the Tshwane University of Technology (TUT) “this small fruit, similar to a pumpkin in looks, is presently most popularly used and widely advertised like a weight-loss supplement”.
The comprehensive overview from TUT shows that research indicates that “the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid part of the fruit rind, exhibited anti-obesity activity”. It also regulates the serotonin levels relevant to satiety, creating reduced intake of food.
“As outlined by clinical trial reports, Garcinia extracts were beneficial to obese individuals on many occasions. Moreover, studies about the toxicity and observations during clinical trials indicate that Garcinia is safe for use. Most of the negative reports are already associated with cases when multi ingredient formulations were consumed along with the effect could not be attributed to a particular ingredient.”
The studies does, however, caution against an increase in serotonin, especially in those who take medicines that happen to be already increasing serotonin levels, for example SSRIs. Research into these effects has not been conducted.
“Moreover, regulatory authorities should provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the research concluded.
Dr Ingrid van Heerden, an authorized dietitian, is of opinion that people needs to be cautious of cambogia garcinia, as it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once an individual who wants, or needs to shed pounds, is totally hooked on the promise of a slim, sexy figure, these are sucked to the deception. In case the drops, wafers or powders don’t work, well then its the fault from the user who did not abide by one or other often impossible instruction such as “stick to a 500 kcal/day diet” or “drink 5 litres of water a day”, never that from the diet pill.
When eventually science and legislation meet up with the manufacturers, they calmly take product A off the market, change their formulation slightly, alter the name to product B, then blithely sell product B using the same advertising gambits as before, raking within the money and pulling the wool over everyone’s eyes all over again.
In keeping with the ever-changing slimming product ranges, you will find what anybody can call “ingredients of the season” (sometimes an ingredient lasts for only three to six months, however, some have longer life spans, after which of course some are resurrected every two to three years).
We now have had apple cider vinegar (which contains made many a comeback throughout the years), green leaf tea (that has earned some merit in scientific studies), hoodia (which just is not going to find a way to produce the research results that will make it a front-runner), willow bark (or salicylic acid which will work for aches and pains however, not as efficacious for slimming), and classic caffeine (that has a diuretic effect thus assisting you lose fat before you replenish the liquid within your body, as well as a stimulant effect when taken in big amounts that may be potentially dangerous), to name but several.
Though it may be perfectly probable that more extensive and well controlled scientific research will disclose an extract of Garcinia cambogia that contains a chemical called hydroxycitric acid (HCA) can assist weight reduction, we have been at the moment not even sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it might or might not have and what dosage must achieve really significant weight loss.
Nevertheless I hear you say: “For once there exists a number of scientific tests that had been completed with Garcinia cambogia, so what’s the issue?”
Well some of the studies did not show any fat loss differences between patients who took Garcinia pills and those who took dummy pills, while other studies did show variations in weight loss with the subjects taking pills containing Garcinia losing slightly more weight than those that failed to (Marquez et al, 2012).
Some of these weight-loss differences were not exactly exciting either, so that we can’t say for certain that Garcinia cambogia does promote weight-loss. Additionally, it seems likely that this may not be the wonder pill it really is made out to be.
Additionally, a lot of the studies conducted currently happen to be flawed (Critchley, 2013) . What it means is for example that in just one study the control and experimental subjects were not well matched (i.e. they was without the same starting weight, age, portion of body fat etc.), while in other studies too few subjects were utilised to the results to be significant.
For your results of studies to become plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and you also need not just some subjects to produce a similar result.
In the positive side, we could claim that there is some evidence that Garcinia cambogia products may aid weight reduction over a duration of 12 weeks. No studies have been conducted for prolonged periods as yet (Marquez et al, 2012), and this is considered to be a drawback.
There is also at the moment an argument in regards to the safety of pills containing Garcinia cambogia – one number of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez and his coworkers (2012) state that “at the doses usually administered, no differences happen to be reported when it comes to adverse reactions or adverse events (those studied) in humans between individuals given G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the usa has published a warning about the hepatotoxicity of a weight loss product called “Hydroxycut”, which contains Garcinia cambogia. The author collected case reports of patients who developed liver toxicity associated with the above mentioned weight reduction product.
Evidently approximately 1 million units with this hydroxycitric acid product can be purchased annually in the united states. The patients who developed hepatotoxicity reported symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the quantity of hepatotoxicity cases reported were hardly any, Lob indicates that monitoring of adverse events related to health supplements such as these weight loss products is woefully inadequate in the us (as is the situation in numerous other countries, including South Africa), together with the FDA only receiving about 1% of these negative reports.
According to Lob (2009), the Poison Control Centres in the USA will probably receive reports of adverse events linked to vitamin supplements but they are not equipped to coordinate such findings.
He cites the truly sobering demonstration of something called “Metabolife 356″ that was sold as a diet supplement in the us. Lob’s states the manufacturers received 14 000 reports over a period of 5yrs that documented “serious adverse events associated with their ephedra-containing product” which dexrpky17 heart attacks, strokes, convulsions and fatalities.
The makers failed to inform the FDA or any other US government authority of these reports. As astounding since this might sound, manufacturers of health supplements usually are not required to meet the specifications that are strictly enforced in relation to food and pharmaceutical products (medicines), to allow them to take advantage of this “ethical loophole” not to publish reports of negative and harmful events.
Eventually these events arrived at light and ephedra-containing products for slimming and other uses were banned in the USA.
The implication contain in Lob’s warning is that HCA or Garcinia cambogia extract will also be potentially toxic unless sufficient, reliable evidence towards the contrary is manufactured available.
With the present moment, we have no idea enough about slimming products which contain pure garcinia cambogia side effects to freely recommend its use. I have a tendency to agree with Astell and coworkers (2013) who conducted a systematic article on double blind randomised controlled clinical studies to assess evidence available on the efficacy of current vitamin supplements accustomed to control appetite and/or weight.
These authors determined that “According on the finding with this systematic review, evidence is just not convincing in demonstrating that a lot of health supplements used as appetite suppressants for weight-loss in dealing with obesity work well and safe.”
While we wait around for more extensive and conclusive evidence obtained with larger variety of well-matched test subjects treated for longer periods with all the “gold standard” of double blind randomised controlled numerous studies, rather avoid using any weight-loss supplement that has not been tested thoroughly.